A drug-drug interaction study to evaluate the impact of peficitinib on OCT1- and MATE1-mediated transport of metformin in healthy volunteers.
作者： Mai Shibata , Junko Toyoshima , Yuichiro Kaneko , Kazuo Oda , Tetsuya Nishimura
DOI: 10.1007/S00228-020-02876-2
关键词: Organic cation transport proteins 、 Urine 、 Pharmacology 、 Renal physiology 、 Metformin 、 Rheumatoid arthritis 、 Metabolite 、 Cmax 、 Medicine 、 Pharmacokinetics
摘要: … of peficitinib on … peficitinib and H2 (the metabolite of peficitinib with the highest exposure) with the human metformin transporters OCT1, OCT2, MATE1 and MATE2-K in vitro. Peficitinib …
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