Verapamil decreases the glucose-lowering effect of metformin in healthy volunteers
作者： Sung Kweon Cho , Choon Ok Kim , Eun Seok Park , Jae-Yong Chung
DOI: 10.1111/BCP.12476
关键词:
摘要: Aim The organic cation transporter 1 (OCT1) plays a key role in the cellular transport of metformin and its subsequent glucose-lowering effect. A recent non-clinical study reported that uptake into hepatocytes is regulated via OCT1, was strongly inhibited by verapamil. Therefore, we investigated effects verapamil co-administration on pharmacokinetics pharmacodynamics humans.
sci-hub.se 参考文章(30)
Atsushi Yonezawa, Ken-ichi Inui, Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics British Journal of Pharmacology. ,vol. 164, pp. 1817- 1825 ,(2011) , 10.1111/J.1476-5381.2011.01394.X
GT Tucker, C Casey, PJ Phillips, H Connor, JD Ward, HF Woods, Metformin kinetics in healthy subjects and in patients with diabetes mellitus. British Journal of Clinical Pharmacology. ,vol. 12, pp. 235- 246 ,(1981) , 10.1111/J.1365-2125.1981.TB01206.X
Thomas Mettang, Oliver Burk, Michel Eichelbaum, Martin F. Fromm, Oliver von Richter, Christiane Pauli-Magnus, Anja Ziegler, Characterization of the Major Metabolites of Verapamil as Substrates and Inhibitors of P-glycoprotein Journal of Pharmacology and Experimental Therapeutics. ,vol. 293, pp. 376- 382 ,(2000)
S L Stocker, K M Morrissey, S W Yee, R A Castro, L Xu, A Dahlin, A H Ramirez, D M Roden, R A Wilke, C A McCarty, R L Davis, C M Brett, K M Giacomini, The Effect of Novel Promoter Variants in MATE1 and MATE2 on the Pharmacokinetics and Pharmacodynamics of Metformin Clinical Pharmacology & Therapeutics. ,vol. 93, pp. 186- 194 ,(2013) , 10.1038/CLPT.2012.210
Gustav Ahlin, Johan Karlsson, Jenny M. Pedersen, Lena Gustavsson, Rolf Larsson, Pär Matsson, Ulf Norinder, Christel A. S. Bergström, Per Artursson, Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of Medicinal Chemistry. ,vol. 51, pp. 5932- 5942 ,(2008) , 10.1021/JM8003152
Matthijs L. Becker, Loes E. Visser, Ron H. N. van Schaik, Albert Hofman, André G. Uitterlinden, Bruno H. Ch. Stricker, Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response. Pharmacogenetics and Genomics. ,vol. 20, pp. 38- 44 ,(2010) , 10.1097/FPC.0B013E328333BB11
Yan Shu, Steven A. Sheardown, Chaline Brown, Ryan P. Owen, Shuzhong Zhang, Richard A. Castro, Alexandra G. Ianculescu, Lin Yue, Joan C. Lo, Esteban G. Burchard, Claire M. Brett, Kathleen M. Giacomini, Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. Journal of Clinical Investigation. ,vol. 117, pp. 1422- 1431 ,(2007) , 10.1172/JCI30558
Karen Engel, Joanne Wang, Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Molecular Pharmacology. ,vol. 68, pp. 1397- 1407 ,(2005) , 10.1124/MOL.105.016832
Michael Levine, Edward W. Boyer, Charles N. Pozner, Ann-Jeannette Geib, Todd Thomsen, Nathan Mick, Stephen H. Thomas, Assessment of hyperglycemia after calcium channel blocker overdoses involving diltiazem or verapamil* Critical Care Medicine. ,vol. 35, pp. 2071- 2075 ,(2007) , 10.1097/01.CCM.0000278916.04569.23
Noritaka Nakamichi, Hiroyo Shima, Satoshi Asano, Takahiro Ishimoto, Tomoko Sugiura, Kazuki Matsubara, Hiroyuki Kusuhara, Yuichi Sugiyama, Yoshimichi Sai, Ken-ichi Miyamoto, Akira Tsuji, Yukio Kato, Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin. Journal of Pharmaceutical Sciences. ,vol. 102, pp. 3407- 3417 ,(2013) , 10.1002/JPS.23595