Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics
作者： Atsushi Yonezawa , Ken-ichi Inui
DOI: 10.1111/J.1476-5381.2011.01394.X
关键词:
摘要: The renal organic cation transport system mediates the tubular secretion of cationic compounds including drugs, toxins and endogenous metabolites into urine. It consists a membrane potential-dependent transporter at basolateral an H+/organic antiporter brush-border membrane. In 2005, human multidrug toxin extrusion MATE1/SLC47A1 was identified as mammalian homologue bacterial NorM. Thereafter, MATE2-K/SLC47A2 rodent MATE were found. Functional characterization revealed that MATE1 MATE2-K antiporter, mediating drugs in cooperation with OCT2. Recently, substrate specificity, transcription mechanisms, structure, polymorphisms, vivo contributions clinical outcomes on have been investigated intensively. this review, we summarize recent findings discuss importance these transporters to pharmacokinetics, pharmacodynamics/toxicodynamics pharmacogenomics drugs.
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