Effect of cimetidine on renal and hepatic drug elimination: studies with triamterene.

摘要: A chronic-dosing pharmacokinetic study was carried out in six healthy subjects to examine the potential for Cimetidine reduce CLR and CLHof triamterene. Blood urine samples were collected frequently 24 hours after dosing with triamterene alone (100 mg/day) 4 days concomitant (400 mg twice daily) an additional days. significantly reduced clearance of by hydroxylation 32% (P < 0.016) 28% 0.063), no change its protein binding. The active sulfate conjugate not altered Cimetidine. There a recovery metabolites Cimetidine, suggesting decreased absorption. These results are consistent inhibiting cytochrome P-450 enzymes liver also competing renal tubular secretion. Despite interaction, caused minimal alteration natriuretic antikaliuretic effects triamterene. Clinical Pharmacology Therapeutics (1986) 40, 400–407; doi:10.1038/clpt.1986.197