Renal transport of drugs: an overview of methodology with application to cimetidine.

摘要: The development of new methods to study transport processes in renal epithelia has greatly enhanced our knowledge the mechanisms involved a number endogenous compounds. More recently, these have been applied specific drug transport. This article is intended provide an overview various used elimination References more detailed reviews individual are provided. Studies cimetidine, histamine H2-receptor antagonist, presented illustrate application drugs. Methods such as clearance techniques and Sperber chicken preparation compounds whole animals briefly described. Techniques identify site including stop flow, isolated perfused tubules, micropuncture discussed references technical cited. recently developed membrane vesicles for studying across polar membranes proximal tubule along with relevant studies use elucidating cimetidine. Finally, cultured epithelial cell lines Knowledge kidney important both targeting understanding pharmacokinetics renally eliminated As exemplified by only combining data from experiments using diverse methodology can excretion be delineated. With existing technologies, many questions related addressed.