Structural and Numerical Aberrations of Chromosome 22 in a Case of Follicular Variant of Papillary Thyroid Carcinoma Revealed by Conventional and Molecular Cytogenetics
作者： Bernard Perissel , Isabelle Coupier , Monique De Latour , Nathalie Cardot , Frédérique Penault-Llorca
DOI: 10.1016/S0165-4608(00)00228-4
关键词: Molecular biology 、 Cytogenetics 、 Karyotype 、 Biology 、 Locus (genetics) 、 Chromosome 22 、 Aneuploidy 、 Fluorescence in situ hybridization 、 Molecular cytogenetics 、 Chromosomal translocation 、 Genetics
摘要: This study reports a case of papillary carcinoma with vesicular components showing multiclonal aberrations chromosome 22 as revealed by RHG-banding cytogenetics and fluorescence in situ hybridization (FISH; whole BCR-ABL-specific locus probes, multi-FISH). Four clones changes the sole abnormality were seen. The main abnormal clone lacked 22. A del(22)(q11) was observed second group cells. third had an idic(22). Finally, FISH fourth cell population der(17)t(?17;22). Some these alterations have been described other solid tumors such meningiomas neurinomas, suggesting common genetic pathway tumor progression occurring multistep process. Chromosome do not seem to be involved pure thyroid therefore could related maintenance follicular-type histological pattern.
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