Fatal Hemorrhage of a Supratentorial Extraventricular Anaplastic Ependymoma in an Elderly Patient

作者: Tooru Inoue , Kazuki Nabeshima , Hiromasa Kobayashi , Tadahiro Ohmura , Takeo Fukushima

DOI:

关键词: SurgeryAnaplastic EpendymomaTemozolomideAdjuvant therapyElderly patientGliomaAdjuvant chemotherapyChemotherapyMedicineComa

摘要: Introduction: Intracranial ependymomas are less common in adults, and supratentorial extraventricular anaplastic requiring emergency surgery extremely rare. In addition, effective adjuvant chemotherapy for ependymoma has not been defined, especially adults. We herein describe a rare case of with fatal intratumoral hemorrhage discuss the therapy malignant glioma patients poor cognitive function. Case report: A 69-year-old female presented large area manifesting as sudden coma. cauliflower-like tumor was found primarily left inferior frontal gyrus unattached to lateral ventricle. The histologic features were consistent those ependymoma. Due patient’s age impaired function, we administered only temozolomide therapy. Conclusion: Maximal surgical resection is valuable treatment option

参考文章(11)
L. Palma, P. Celli, A. Mariottini, A. Zalaffi, G. Schettini, The importance of surgery in supratentorial ependymomas. Long-term survival in a series of 23 cases. Childs Nervous System. ,vol. 16, pp. 170- 175 ,(2000) , 10.1007/S003810050487
CF Freyschlag, J Tuettenberg, F Lohr, C Thomé, K Schmieder, M Seiz, None, Response to Temozolomide in Supratentorial Multifocal Recurrence of Malignant Ependymoma Anticancer Research. ,vol. 31, pp. 1023- 1025 ,(2011)
Marc C. Chamberlain, Sandra K. Johnston, Temozolomide for recurrent intracranial supratentorial platinum‐refractory ependymoma Cancer. ,vol. 115, pp. 4775- 4782 ,(2009) , 10.1002/CNCR.24524
Atsuhiro Kojima, Noriyuki Yamaguchi, Shunichi Okui, Makoto Kamiya, Junko Hirato, Yoichi Nakazato, Parenchymal anaplastic ependymoma with intratumoral hemorrhage: a case report. Brain Tumor Pathology. ,vol. 20, pp. 85- 88 ,(2003) , 10.1007/BF02483452
Matthew J. Davis, Fauzia Hasan, Ilan Weinreb, M. Christopher Wallace, Tim-Rasmus Kiehl, Extraventricular anaplastic ependymoma with metastasis to scalp and neck. Journal of Neuro-oncology. ,vol. 104, pp. 599- 604 ,(2011) , 10.1007/S11060-010-0525-X
Norman L. Lehman, Patterns of brain infiltration and secondary structure formation in supratentorial ependymal tumors. Journal of Neuropathology and Experimental Neurology. ,vol. 67, pp. 900- 910 ,(2008) , 10.1097/NEN.0B013E31818521CD
Flávio Ramalho Romero, Marco Antônio Zanini, Luis Gustavo Ducati, Roberto Bezerra Vital, Newton Moreira de Lima Neto, Roberto Colichio Gabarra, Purely cortical anaplastic ependymoma. Case reports in oncological medicine. ,vol. 2012, pp. 541431- 541431 ,(2012) , 10.1155/2012/541431
Naotaka Iwamoto, Yasuo Murai, Yoichiro Yamamoto, Koji Adachi, Akira Teramoto, Supratentorial extraventricular anaplastic ependymoma in an adult with repeated intratumoral hemorrhage Brain Tumor Pathology. ,vol. 31, pp. 138- 143 ,(2014) , 10.1007/S10014-013-0146-0
Karen D. Wright, Amar Gajjar, Current Treatment Options for Pediatric and Adult Patients With Ependymoma Current Treatment Options in Oncology. ,vol. 13, pp. 465- 477 ,(2012) , 10.1007/S11864-012-0205-5
Toba N. Niazi, Elizabeth M. Jensen, Randy L. Jensen, WHO Grade II and III supratentorial hemispheric ependymomas in adults: case series and review of treatment options Journal of Neuro-Oncology. ,vol. 91, pp. 323- 328 ,(2009) , 10.1007/S11060-008-9717-Z