Interleukin-4 receptor regulation in human monocytic cells.
作者： H de Wit , DW Hendriks , MR Halie , E Vellenga
DOI: 10.1182/BLOOD.V84.2.608.608
关键词: Cell surface receptor 、 Internal medicine 、 Cytokine 、 Interleukin-4 receptor 、 Interleukin 4 、 CD14 、 Colony-stimulating factor 、 Endocrinology 、 Receptor 、 Protein kinase A 、 Cell biology 、 Biology
摘要: The regulation of the interleukin-4 receptor (IL-4R) was studied at mRNA and protein level in monocytic cells on stimulation with activators different intracellular signaling pathways IL-4. Activation kinase C-dependent phorbol myristate acetate (PMA) or activation A-dependent DBcAMP prostaglandin E2 resulted an augmented IL- 4R expression level. Transcriptional posttranscriptional mechanisms seemed to be involved promotive effect because transcription rate increased 1.8-fold, half-life IL-4R prolonged 150 minutes compared 120 unstimulated cells. In contrast, PMA could only ascribed changes transcriptional However, Ca(2+)-dependent A23187 IL-4 had no expression. unresponsiveness 4 not a nonfunctional did modulate CD14, CD23, HLA-DR antigen These results are contrast T cells, which is affected by IL-4- pathways. discrepancy might caused presence common IL-2 gamma chain (gamma c) absence c as has been shown polymerase reaction. data indicate that IL-4Rs differentially regulated, depending cell type studied.
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