Probes for hidden hyperdiploidy in acute lymphoblastic leukaemia
作者： Anthony V. Moorman , Roslyn Clark , Dianna M. Farrell , Jacqueline M. Hawkins , Mary Martineau
DOI: 10.1002/(SICI)1098-2264(199605)16:1<40::AID-GCC6>3.0.CO;2-3
关键词:
摘要: The detection of hyperdiploidy (clones with >46 chromosomes) in the bone marrow patients acute lymphoblastic leukaemia (ALL) is important because prognostic impact this finding. high hyperdiploid (HeH) subgroup 51-68 chromosomes associated best outcome, followed by low (HeL) 47-50 and triploid/tetraploid (TT) >68 chromosomes, which do less well. We present a strategy for use fluorescence situ hybridization (FISH) chromosome-specific probes to detect interphase cells assign cases ploidy subgroup. By using model population 252 cases, it was seen that ten (X, 4, 6, 8, 10, 14, 16, 18, 20, 21) used particular combinations applied step-wise manner enabled 94% gave an accurate prediction 96% these cases. classification each case required four six over two or three steps. Confirmation will achieve level other populations demonstrated 250 published karyotypes. This has application detecting missing hidden among failed normal cytogenetics.
elsevier.com
sci-hub.se 参考文章(17)
H de Wit, DW Hendriks, MR Halie, E Vellenga, Interleukin-4 receptor regulation in human monocytic cells. Blood. ,vol. 84, pp. 608- 615 ,(1994) , 10.1182/BLOOD.V84.2.608.608
CH Pui, AJ Carroll, D Head, SC Raimondi, JJ Shuster, WM Crist, MP Link, MJ Borowitz, FG Behm, VJ Land, Near-triploid and near-tetraploid acute lymphoblastic leukemia of childhood. Blood. ,vol. 76, pp. 590- 596 ,(1990) , 10.1182/BLOOD.V76.3.590.BLOODJOURNAL763590
AT Look, PK Roberson, DL Williams, G Rivera, WP Bowman, CH Pui, J Ochs, M Abromowitch, D Kalwinsky, GV Dahl, Prognostic importance of blast cell DNA content in childhood acute lymphoblastic leukemia. Blood. ,vol. 65, pp. 1079- 1086 ,(1985) , 10.1182/BLOOD.V65.5.1079.1079
CH Pui, SC Raimondi, RK Dodge, GK Rivera, LA Fuchs, M Abromowitch, AT Look, WL Furman, WM Crist, DL Williams, Prognostic importance of structural chromosomal abnormalities in children with hyperdiploid (greater than 50 chromosomes) acute lymphoblastic leukemia Blood. ,vol. 73, pp. 1963- 1967 ,(1989) , 10.1182/BLOOD.V73.7.1963.1963
WJ Kraker, TJ Borell, L Penland, RB Jenkins, A Fernald, EM Davis, R d Espinosa, MM Le Beau, DJ Schaid, PG Stalboerger, Fluorescence in situ hybridization: a sensitive method for trisomy 8 detection in bone marrow specimens. Blood. ,vol. 79, pp. 3307- 3315 ,(1992) , 10.1182/BLOOD.V79.12.3307.3307
SC Raimondi, PK Roberson, CH Pui, FG Behm, GK Rivera, Hyperdiploid (47-50) acute lymphoblastic leukemia in children. Blood. ,vol. 79, pp. 3245- 3252 ,(1992) , 10.1182/BLOOD.V79.12.3245.3245
E B Hook, Exclusion of chromosomal mosaicism: tables of 90%, 95% and 99% confidence limits and comments on use American Journal of Human Genetics. ,vol. 29, pp. 94- 97 ,(1977)
MB Harris, JJ Shuster, A Carroll, AT Look, MJ Borowitz, WM Crist, R Nitschke, J Pullen, CP Steuber, VJ Land, Trisomy of leukemic cell chromosomes 4 and 10 identifies children with B-progenitor cell acute lymphoblastic leukemia with a very low risk of treatment failure: a Pediatric Oncology Group study. Blood. ,vol. 79, pp. 3316- 3324 ,(1992) , 10.1182/BLOOD.V79.12.3316.3316
J. F. Jackson, J. Boyett, J. Pullen, B. Brock, R. Patterson, V. Land, M. Borowitz, D. Head, W. Crist, Favorable prognosis associated with hyperdiploidy in children with acute lymphocytic leukemia correlates with extra chromosome 6. A pediatric oncology group study Cancer. ,vol. 66, pp. 1183- 1189 ,(1990) , 10.1002/1097-0142(19900915)66:6<1183::AID-CNCR2820660618>3.0.CO;2-P
Serge P. Romana, Dorra Cherif, Maryvonne Le Coniat, Josette Derré, Marie-Ange Flexor, Roland Berger, In situ hybridization to interphase nuclei in acute leukemia Genes, Chromosomes and Cancer. ,vol. 8, pp. 98- 103 ,(1993) , 10.1002/GCC.2870080206