Cytogenetic Profile of Childhood Acute Lymphoblastic Leukemia in Oman

摘要: Background Chromosomal abnormalities have important diagnostic and prognostic significance in acute lymphoblastic leukemia (ALL). The purpose of this study was to define classify the frequency type chromosomal among newly diagnosed children with ALL compare results those reported from other geographical regions world. Methods Bone marrow studies GTG banding were performed untreated pediatric patients aged 7 days 14 years. Results Among Omani examined ALL, 47 (81%) yielded results, 26 (55.3%) showing an abnormal karyotype [10 (21.3%) pseudodiploid, 2 (4.3%) hypodiploid (29.7%) hyperdiploidy] 21 (44.6%) had normal diploidy. Structural observed 16 (34%), which 11 (23.4%) cases translocations, most frequent being t(9;22) three (6.4%) our patients. Uncommon translocations such as t(9;15)(p11;q10), t(3;6)(p12;q11), t(1;6)(?31;?q23), t(1;19)(q12;q12), der(18)t(12;18)(q11;p11), structural aberrations add(2)(q22), add(6)(q16), add(18)(q22), add(14)(q32) along deletions del(10)(q22), del(12)(p11), del(12)(p12), del(18)(q11) also observed. Conclusions showed a good correlation concordance between ploidy distribution by cytogenetics flow cytometry. patterns anomalies some variations reported. It is therefore necessary that newer techniques like fluorescence situ hybridization (FISH) reverse transcriptase polymerase chain reaction (RT-PCR) spectral karyotyping will help us identify not detected conventional cytogenetic methods near future. To knowledge, first report Middle East on childhood ALL.