Nanomaterials for targeted drug delivery to cancer stem cells

摘要: Recent developments in cancer biology have identified the existence of a sub-poplulation cells - stem (CSC) that are resistant to most traditional therapies (e.g. chemotherapy and radiotherapy) ability repair their damaged DNA. These findings necessitated break with oncology management encouraged new perspectives concerning treatment. Understanding functional CSCs especially signaling pathways involved self-renewal mechanisms is crucial for discovering forms In this review, we highlight current future prospects potential based on use nano-sized materials. Nanomaterials could revolutionize because distinctive features unique surface chemistry, strong electronic, optic, magnetic properties found neither bulk materials nor single molecules. Based these distinct properties, believe nanomaterials be excellent candidates CSC research order optimize therapeutics. Moreover, propose inhibition by focusing Hedgehog, Notch, Wnt/β-catenin mechanisms. By introducing methods detection, targeting, destruction CSCs, an efficient alternative treatment incurable disease provided.