Endothelial Activation, Innate Immune Activation, and Inflammation Are Associated With Postbronchodilator Airflow Limitation and Obstruction Among Adolescents Living With HIV.

摘要: BACKGROUND Chronic inflammation, innate immune activation, T-cell imbalance and endothelial activation have been linked with lung diseases. We sought to determine whether markers of these pathophysiologic pathways were associated spirometry chest computed tomography (CT) abnormalities among adolescents living HIV (ALWH). SETTING Coptic Hope Center for Infectious Diseases in Nairobi, Kenya. METHODS performed a cross-sectional study ALWH (10-19 years old). Participants underwent CT, spirometry, venipuncture serum biomarkers. also collected demographic, anthropometric, subset, antiretroviral therapy, exposure data. compared characteristics biomarkers by airflow obstruction [postbronchodilator FEV1/FVC z-score (zFEV1/FVC) < -1.64]. used multivariable linear regression associations log10-transformed CT lower postbronchodilator zFEV1/FVC (airflow limitation). exploratory principal components analysis on biomarkers, determined factors abnormalities. RESULTS Of 47 participants acceptable quality 21 (45%) female, median age was 13 96% had perinatally-acquired HIV. Median CD4 672 cells/µL. Overall, 28% 78% abnormality; mosaic attenuation (P = 0.001). Higher (sVCAM-1, sICAM-1), inflammation (serum amyloid-A, sTREM-1, sCD163), (lower CD4/CD8) limitation. Factors comprising CONCLUSIONS Endothelial imbalance, chronic are limitation obstruction, providing insights into disease pathophysiology ALWH.