作者: A. M. Sillito , P. C. Murphy , T. E. Salt , C. I. Moody
关键词: Antagonist 、 NMDA receptor 、 Endocrinology 、 Neurotransmission 、 Kainate receptor 、 Electrophysiology 、 Chemistry 、 Receptive field 、 Neuroscience 、 Glutamate receptor 、 Internal medicine 、 Receptor
摘要: 1. We have examined the possibility that N-methyl-D-aspartate (NMDA) receptors may be involved in visual response of relay cells cat dorsal lateral geniculate nucleus (dLGN). The selective NMDA receptor antagonists D-2-amino-5-phosphonovalerate (APV) and 3-[(+/-)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (CPP) been iontophoretically applied to X Y dLGN their effects on a light spot flashed within receptive field center determined. 2. antagonist were assessed at ejection current levels producing blockade responses with respect those elicited by non-NMDA agonists quisqualate kainate. These determined an experimental paradigm where compared same test run. data refer total population 52 (28 X, 24 Y). 3. Application APV abolished or greatly reduced both cells. mean percentage reduction for studied was 59 +/- 10% (SE; n = 7) 66 8% 11). Both early onset transient sustained component stimulus equally affected. 4. CPP produced similar pattern effect APV, substantially reducing abolishing cells.(ABSTRACT TRUNCATED AT 250 WORDS)