The cholinergic neuromodulatory system: an evaluation of its functional roles.

摘要: Publisher Summary The cholinergic modulation of the visual system at thalamic and neocortical levels provides access to some functional logic that pertains ones broader understanding role central systems. Broadly, joint influence seems increase excitatory response appropriate sensory stimuli in stimulus selective network cortex. This reflects an enhanced level responsiveness dLGN relay cells, higher activity cortical inhibitory circuits modifications pyramidal cell via voltage calcium dependent potassium currents. issue disinhibition is complex but several factors should be borne mind. interactions triadic synapse discussed this chapter. tendency diminish interneurones needs balanced against feedback from Finally, chapter discusses possible impact a reduction magnocellular nuclei basal forebrain context arguments presented. Two consequences could be, effective strength enhancement geniculate circuits. If subcortical was unaffected, outcome more potent less regulated input cortex diminished capacity circuitry control its effect. Such influences play pathology linked Alzheimer's disease.