The Cholinergic Modulation of Cortical Function

摘要: The cholinergic input to neocortex has long been considered mediate a non-specific influence over its function (Hebb, 1957; Shute and Lewis, 1967, Szerb, Spehlmann, 1971) rather than convey specific thalamic inputs (Spehlmann et al. 1971). general view that it produces the changes in cortical are normally associated with arousal (Singer, 1979). However, not only does situation appear be more complex earlier work suggested, but we now have much greater insight into mechanisms of action acetylcholine (ACh) at pre- postsynaptic levels. In this account I shall attempt bring together summary various components our knowledge regarding innervation possible function, then discuss ways which system may interact other nonspecific neocortex. Some sections will draw heavily on information available for visual cortex because is date one best models have. While there tendency regard as simply shifting backwards forwards between sleeping waking states, what emerges picture. interplay systems appears very subtle; suggests roles selective attention interactions control blood flow, metabolism, brain plasticity.