Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention.
作者： Shivani S. Desai , Elysa J. Marco , Eva M. Palacios , Pratik Mukherjee , Annie Brandes-Aitken
DOI: 10.3389/FPSYG.2020.618436
关键词: Cerebellum 、 Sensory processing 、 Diffusion MRI 、 Neuroscience 、 Fractional anisotropy 、 Sensory system 、 White matter 、 Cerebellar white matter 、 Psychology 、 Multisensory integration
摘要: Sensory processing dysfunction (SPD) is characterized by a behaviorally observed difference in the response to sensory information from environment. While cerebellum involved normal processing, it has not yet been examined SPD. Diffusion tensor imaging scans of children with SPD (n = 42) and typically developing controls (TDC; n 39) were compared for fractional anisotropy (FA), mean diffusivity (MD), radial (RD), axial (AD) across following cerebellar tracts: middle peduncles (MCP), superior (SCP), cerebral (CP). Compared TDC, show reduced microstructural integrity SCP MCP, FA increased MD RD, which correlates abnormal auditory behavior, multisensory integration, attention, but tactile behavior or direct measures discrimination. In contradistinction, decreased CP discrimination, integration attention. Hence, altered white matter organization associated complex attention SPD, prompts further consideration diagnostic treatments better serve affected individuals.
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