Effective Synthesis of N-Arylformamide from α-Halo-N-arylacetamides
作者： Kun-Heng Chiang , Shi-Han Lu , Wan-Ping Yen , Naoto Uramaru , Wei-Siou Tseng
DOI: 10.1002/HC.21321
关键词: Acetamide 、 Computational chemistry 、 Chemistry 、 Formamide 、 Halo
摘要: A convenient synthetic method for N-arylformamide derivatives was successfully developed by reacting α-iodo-N-arylacetamides with formamide. This applicable to α-iodo-N-arylacetamide substrates bearing electron-donating or electron-withdrawing groups, N-(benzo[d][1,3]dioxol-5-yl)-2-iodoacetamide, 2-iodo-N-(pyridin-2-yl)acetamide, and 2-iodo-N-(naphthalen-4-yl)acetamide give the corresponding N-arylformamides in moderate excellent yields (65–94%). plausible mechanism proposed account new transformation.
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