Vilsmeier reagent-mediated synthesis of 6-[(formyloxy)methyl]-pyrazolopyrimidines via a one-pot multiple tandem reaction
作者： Shi-Han Lu , Po-Lin Liu , Fung Fuh Wong
DOI: 10.1039/C5RA07707A
关键词: Hydrolysis 、 Cascade reaction 、 Reagent 、 Organic chemistry 、 Pyrimidine 、 Chemistry
摘要: A new Vilsmeier reagent-mediated one-pot reaction using 5-(2-chloroacetylamino)pyrazoles as the starting material was developed for efficient synthesis of 6-[(formyloxy)methyl]-1H-pyrazolo[3,4-d]pyrimidine. This multiple tandem reaction, involving Vilsmeier–Haack Morgan–Walls sequential elimination, substitution, and final hydrolysis, afforded formyloxymethyl pyrazolo[3,4-d]pyrimidine products in good yields.
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