Renal Hemodynamics in Acute Unilateral Ureteral Obstruction: Contribution of Endothelium-Derived Relaxing Factor
作者： Joseph A. Lanzone , Frederick A. Gulmi , Shyan-Yih Chou , Unni M.M. Mooppan , Hong Kim
DOI: 10.1016/S0022-5347(01)67401-9
关键词: Fissipedia 、 Renal artery 、 Hemodynamics 、 Urology 、 Renal blood flow 、 Ureter 、 Nitric oxide 、 Medicine 、 Carnivora 、 Surgery 、 Endothelium-derived relaxing factor
摘要: AbstractThe increase in ureteral pressure after acute unilateral obstruction (UUO) is associated with an initial renal blood flow (RBF). The present study examines the role of nitric oxide, a major endothelium-derived relaxing factor (EDRF), UUO-induced hyperemia anesthetized dogs. In Group 1, vehicle solution was infused into left artery. 2, oxide formation from L-arginine competitively inhibited by intrarenal infusion Nomega-monomethyl-L-arginine (L-NMMA) (50 microgram/kg./min.) before UUO. 3, (2 mg./kg./min.) together L-NMMA After UUO, increased all groups, averaging 69 mm.Hg. RBF at 10 and 20 minutes UUO 7.9 plus/minus 1.6 percent 16.5 5.2 percent, respectively, significantly greater than 2 (1.2 2.4 1.5 percent). discontinued in...
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