Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.
作者： R Dorajoo , AIF Blakemore , X Sim , R TH Ong , DPK Ng
DOI: 10.1038/IJO.2011.86
关键词: Genetic predisposition 、 Single-nucleotide polymorphism 、 Locus (genetics) 、 Malay 、 Genome-wide association study 、 Type 2 diabetes 、 Genetic association 、 Genetics 、 Obesity 、 Biology
摘要: Recent genome-wide association studies (GWAS) have identified 38 obesity-associated loci among European populations. However, their contribution to obesity in other ethnicities is largely unknown. We utilised five GWAS (N=10 482) from Chinese (three cohorts, including one with type 2 diabetes and another of children), Malay Indian ethnic groups Singapore. Data sets were analysed individually subsequently combined meta-analysis for Z-score body-mass index (BMI) associations. Variants at the FTO locus showed strongest associations BMI after (P-values 1.16 × 10−7–7.95 10−7). further detected nine variants close MC4R, GNPDA2, TMEM18, QPCTL/GIPR, BDNF, ETV5, MAP2K5/SKOR1, SEC16B TNKS/MSRA (meta-analysis P-values ranging 3.58 10−4–1.44 10−2). Three single-nucleotide polymorphisms (SNPs) CADM2, PTBP2 FAIM2 associated (P-value ⩽0.0418) least dataset. The neurotrophin/TRK pathway (P-value=0.029) was highlighted by pathway-based analysis that had statistically significant Singaporean Our data confirm role predisposition Chinese, Malays Indians, three major Asian groups. additionally 12 SNPs Singaporeans. Thus, it likely Europeans Asians share some genetic obesity. Furthermore, signalling may a central common Asians.
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