Carcinoembryonic antigen in monitoring of response to cetuximab plus FOLFIRI or FOLFOX-4 in patients with metastatic colorectal cancer.
作者： H.L. Tsai , Y.T. Chang , K.S. Chu , C.F. Chen , Y.S. Yeh
关键词: Colorectal cancer 、 Carcinoembryonic antigen 、 Oncology 、 Internal medicine 、 Oxaliplatin 、 FOLFOX 、 Medicine 、 Metastasis 、 Cancer 、 Cetuximab 、 Pathology 、 FOLFIRI
摘要: First-line treatment of metastatic colorectal cancer with combinations cetuximab and irinotecan-based or oxaliplatin-based chemotherapy has shown promising efficacy. The clinical response to such is generally assessed by tumor measurement through imaging. This study was performed evaluate the correlation between serial changes in imaging results carcinoembryonic antigen (CEA) levels. In 64 patients receiving plus FOLFIRI FOLFOX-4 we retrospectively analyzed relationship serum CEA throughout course. Response terms change defined as a >/=50% drop level for more than 4 weeks. sensitivity specificity after targeted relation were 80.5% (33/41) 73.9% (17/23), respectively, diagnostic accuracy 78.1% (50/64). progression-free survival time responders significantly longer that nonresponders (p=0.0091). Our highlight importance monitoring assessing predicting prognosis cancer.
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