CEA monitoring of palliative treatment for colorectal carcinoma.

摘要: Palliative treatment was applied to 131 cases of unresectable or palliatively resected colorectal carcinoma being monitored with serial CEA determinations. There were 84 instances disease progression 67 (80%) them showing an increase in above pretreatment levels maintaining high levels, and 17 (20%) a fall when compared values low initial values. clear-cut regression the only 9 instances. In all 9, clearly dropped maintained valles throughout period regression. No patient had rise elevated level. These changes followed closely clinical response our use particular agent, although for Nitrosourea compounds there may be tendency lower regardless patient's tumor drug. This could due fact that Nitrosoureas produce diffuse block cellular activity, both at nucleous cytoplasm; while other act as alkylating agents by inhibition enzymes involved metabolism nucleic acids (i.e., 5-FU inhibiting thymidylate synthetase). general, longer survival found those patients who initially levels. The favorable (falling value), even many did not show than group rising stable main value monitoring resides its correlation amount present then ability detect mass which is clinically measurable.