Thrombospondin-2 Is Essential for Myocardial Matrix Integrity Increased Expression Identifies Failure-Prone Cardiac Hypertrophy
作者： Blanche Schroen , Stephane Heymans , Umesh Sharma , W. Matthijs Blankesteijn , Saraswati Pokharel
DOI: 10.1161/01.RES.0000141019.20332.3E
关键词: Cardiology 、 Heart failure 、 Biopsy 、 Ejection fraction 、 Medicine 、 Angiotensin II 、 Endocrinology 、 Heart disease 、 Internal medicine 、 Stroke volume 、 Muscle hypertrophy 、 Circulatory system
摘要: Cardiac hypertrophy can lead to heart failure (HF), but it is unpredictable which hypertrophied myocardium will progress HF. We surmised that apart from hypertrophy-related genes, failure-related genes are expressed before the onset of failure, permitting molecular prediction Hearts hypertensive homozygous renin-overexpressing (Ren-2) rats had progressed early HF were compared by microarray analysis Ren-2 remained compensated. To identify HF-related preceded cardiac biopsy specimens taken during compensated and we then monitored whether rat or Among 48 overexpressed in failing hearts, focused on thrombospondin-2 (TSP2). TSP2 was selectively only later Moreover, expression increased human hearts with decreased (0.19±0.01) versus normal ejection fraction (0.11±0.03 [arbitrary units]; P...
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