Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin

摘要: Histone acetylation/deacetylation controls chromatin activity and subsequent gene transcription. Recent studies demonstrated the activation of histone deacetylases (HDACs) in various human malignancies; however, expression function HDACs ovarian tumors are not fully understood. In this study, we examined immunohistochemical HDAC1, HDAC2 HDAC3 using tissues obtained from 115 cases compared it with that Ki-67 (a growth marker), p21, E-cadherin clinicopathological parameters. addition, analyzed effect specific siRNA for on cell cycle-related molecules to clarify functional difference among 3 HDACs. The results indicated nuclear proteins increased stepwise benign, borderline malignant tumors. HDAC1 was correlated inversely expression. Among examined, only associated a poor outcome, when overexpressed. Treatment HDAC inhibitors suppressed proliferation cancer cells association apoptosis. A significantly reduced carcinoma via downregulation cyclin expression, but migration elevated Our suggested plays an important role cells, whereas functions adhesion migration. Therefore, therapeutic approaches should be considered according subtypes.