Evaluation of frequency and the attacks features of patients with colchicine resistance in FMF

摘要: Introduction: Colchicine is the mainstay for treatment of FMF, which an auto-inflammatory disease mainly with relapsing polyserositis. Despite daily doses 2 mg or more each day, approximately 5% to 10% patients continue suffer from its attacks. In this study, we aimed investigate depression and attack features in FMF who have colchicine resistance (CR). Patients e Methods: CR was defined attacks within last 6 months period while using mg/day colchicine. Eighteen (9 Female/9 Male) were enrolled into group 41 control (12 Male/29 Female). Demographic, clinical laboratory findings, adherence, Beck Depression Inventory (BDI) scores evaluated. Results: The age onset significantly lower (12.3 yrs vs. 16.9 yrs, P = 0.03). Disease duration longer (P 0.01). Abdominal leg pain due exercise frequent versus controls (83% 51%; 0.02 88% 60%; 0.04, respectively). BDI over 17 points compared (50% 34.1%; < 0.001). Discussion: We found that: (1) (2) group. Pleuritic attacks, hematuria proteinuria patients. propose that important factor consider susceptibility CR.