Assessment of Epicardial Adipose Tissue Thickness in Children with Familial Mediterranean Fever

作者: Emad E Ghobrial , Yomna M Farag , Doaa M Abdul-Aziz , Mai A Omar

DOI: 10.1093/TROPEJ/FMZ040

关键词: CholesterolGastroenterologyEarly detectionMedicineInternal medicineIncreased riskGene mutationPositive correlationEpicardial adipose tissueSeverity of illnessFamilial Mediterranean fever

摘要: BACKGROUND Familial Mediterranean fever (FMF) is suggested to be associated with increased risk of atherosclerosis. Epicardial adipose tissue (EAT) thickness used in prediction atherosclerotic risk. The aim our study was evaluate EAT FMF patients for early detection atherosclerosis and compared its level healthy controls. METHODS Thirty 6- 18-year-old children 30 age- sex-matched (control group) were included the study. Disease characteristics, disease severity gene mutations recorded. thicknesses measured by echocardiography. RESULTS patients' group significantly greater than that controls (5.21 ± 2.3 vs. 2.81 ± 2.96 mm, p = 0.001) correlated cholesterol platelets count (p = 0.047 0.018, respectively). CONCLUSION This concluded statistically a positive correlation platelet count. finding suggests higher these patients. Follow-up needed verify effect treatment on thickness. Further studies larger number following-up are this finding.

参考文章(27)
Özcan Erel, Semra Işıkoğlu, Salim Neşelioğlu, Hacı Veli Atalay, Ali Şahin, Merve Ergin, Alpaslan Altunoğlu, Şükran Erten, Comparison of serum oxidant and antioxidant parameters in familial Mediterranean fever patients (FMF) with attack free period. Acta Reumatologica Portuguesa. ,vol. 39, pp. 316- ,(2014)
Vassos Neocleous, Constantina Costi, Christina Kyriakou, Tassos C Kyriakides, Christos Shammas, Nicos Skordis, Meropi Toumba, Sophia Kyriakou, Maria Koliou, Marianna Kousparou, Margarita Onoufriou, Adamos Hadjipanayis, Michalis Iasonides, Vick N Atamyan, Alkis Pierides, Violetta Christophidou-Anastasiadou, George A Tanteles, Leonidas A Phylactou, Familial Mediterranean fever associated with MEFV mutations in a large cohort of Cypriot patients. Annals of Human Genetics. ,vol. 79, pp. 20- 27 ,(2015) , 10.1111/AHG.12087
Huda Marzouk, Hala M. Lotfy, Yomna Farag, L. A. Rashed, Kamal El-Garf, Mean Platelet Volume and Splenomegaly as Useful Markers of Subclinical Activity in Egyptian Children with Familial Mediterranean Fever: A Cross-Sectional Study International Journal of Chronic Diseases. ,vol. 2015, pp. 152616- 152616 ,(2015) , 10.1155/2015/152616
Adam Mor, Yael Shinar, Nurit Zaks, Pnina Langevitz, Angela Chetrit, Shmuel Shtrasburg, Einat Rabinovitz, Avi Livneh, Evaluation of disease severity in familial Mediterranean fever. Seminars in Arthritis and Rheumatism. ,vol. 35, pp. 57- 64 ,(2005) , 10.1016/J.SEMARTHRIT.2005.02.002
Gozde Yildirim Cetin, Ayse Balkarli, Ali Nuri Öksüz, Gezmiş Kimyon, Yavuz Pehlivan, Ozlem Orhan, Bunyamin Kisacik, Veli Cobankara, Hayriye Sayarlioglu, Ahmet Mesut Onat, Mehmet Sayarlioglu, Evaluation of frequency and the attacks features of patients with colchicine resistance in FMF Revista Brasileira De Reumatologia. ,vol. 54, pp. 356- 359 ,(2014) , 10.1016/J.RBR.2014.03.022
Shai Padeh, Yakov Berkun, Auto-inflammatory fever syndromes. Rheumatic Diseases Clinics of North America. ,vol. 33, pp. 585- 623 ,(2007) , 10.1016/J.RDC.2007.07.009
Jilke Beinsberger, Johan W.M. Heemskerk, Judith M.E.M. Cosemans, Chronic arthritis and cardiovascular disease: altered blood parameters give rise to a prothrombotic propensity. Seminars in Arthritis and Rheumatism. ,vol. 44, pp. 345- 352 ,(2014) , 10.1016/J.SEMARTHRIT.2014.06.006
Aliza Lipson, Nikolaos Alexopoulos, Gregory Randell Hartlage, Chesnal Arepalli, Annette Oeser, Aihua Bian, Tebeb Gebretsadik, Ayumi Shintani, Arthur E. Stillman, C. Michael Stein, Paolo Raggi, Epicardial adipose tissue is increased in patients with systemic lupus erythematosus Atherosclerosis. ,vol. 223, pp. 389- 393 ,(2012) , 10.1016/J.ATHEROSCLEROSIS.2012.06.006
Dror Dicker, Eli Atar, Ran Kornowski, Gil N. Bachar, Increased Epicardial Adipose Tissue Thickness as a Predictor for Hypertension: A Cross‐Sectional Observational Study Journal of Clinical Hypertension. ,vol. 15, pp. 893- 898 ,(2013) , 10.1111/JCH.12201