The concept of entropy in histopathological diagnosis and targeted therapy

摘要: BackgroundTargeted therapy has been developed to apply individual patient – specific drug regimes that are based upon bio-chemical intra-cellular pathways and usually related cellular proliferation or apoptosis.Entropy Definition Concept Entropy is considered be a physical entity similar space time. It quantifies the distribution of events transport mechanisms in relation macrosystem for thermodynamic, chemical biological processes which analyzed by statistics, communication information methods. amounts distance gross (macro) system from its final stage heat theory; biology entropy flow measures dynamics (distance environment) through surface an open macrosystem, example society, individual, organ, gene, cell, others. A derivative so-called structural internal (enclosed) microstates macrosystem. can computed quantification (vascular) external (outer) surfaces solid tumors, their proliferation.Entropy targeted Therapy The most frequently investigated include onco suppressor genes display with receptors such as epidermal growth factor receptor (EGFR), The presence signalling intensity EFGR set malignant tumors microstate large compartment whole cancer (macrosystem). Thus measure classify dynamic structure associated response patient’s survival.Results The concept tested applied on several cell types including primary lung pulmonary metastases colon cancer. patients’ survival rates were closely corresponding entropies flows. These tests have visualization (Ki-67). extension this breast under investigation.Conclusion The conventional promising tool search understanding structures functions, for  improved analysis serve refinement therapy.