Mechanisms of hyperpolarization in regenerated mature motor axons in cat

摘要: We found persistent abnormalities in the recovery of membrane excitability long-term regenerated motor nerve fibres cat as indicated companion paper. These could partly be explained by hyperpolarization. To further investigate this possibility, we compared changes control nerves and (3–5 years after tibial crush) during manoeuvres known to alter axonal Na+–K+ pump function: polarization, cooling 20°C, reperfusion 10 min ischaemia, up 60 s repetitive stimulation at 200 Hz. The were reduced depolarization increased hyperpolarization postischaemia. Moreover, time course from ischaemia was prolonged nerves. Our data are consistent with an demand for electrogenic pumping leading Such may influence ability axon compensate potential following normal activity.