Deciphering the killer-cell immunoglobulin-like receptor system at super-resolution for natural killer and T-cell biology.

摘要: Killer-cell immunoglobulin-like receptors (KIRs) are components of two fundamental biological systems essential for human health and survival. Firstly, they contribute to host immune response, both innate adaptive, through their expression by natural killer (NK) cells T cells. Secondly, KIR play a key role in regulating placentation, hence reproductive success. Analogous the diversity HLA class I ligands, extremely polymorphic. In this review, we describe recent developments, fuelled methodological advances, which helping decipher system terms haplotypes, polymorphisms, patterns ligand interactions. These developments delivering deeper insight into relevance function, evolution disease. This article is protected copyright. All rights reserved.