The role of KIR and HLA interactions in pregnancy complications

摘要: Combinations of KIR and HLA genes associate with pregnancy complications as well many other clinical scenarios. Understanding how certain influence the biology a disease is, however, formidable challenge. These are two most variable gene families in human genome. Moreover, is best understood by studying cells affected tissue. Natural Killer (NK) express abundant leukocytes uterus. Most our knowledge NK based on what we have learned from isolated blood, but these different their tissue resident counterparts, including uterine (uNK) cells. Reproductive immunology faces an additional challenge: Two genotypes must be considered because both maternal foetal class I molecules may outcome pregnancy, likely through interactions expressed uNK Maternal not spontaneously cytotoxic instead engage trophoblast. We hypothesise that regulate allocation resources between foetus mother go wrong diseases pregnancy.