Iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism in a community-based cohort

摘要: Recent data suggest iodinated contrast media (ICM) exposure is associated with increased risk of incident hyperthyroidism among patients receiving care from two tertiary medical centers. We sought to confirm and generalize these findings by conducting a case-control study broadly-representative community-based cohort within Harvard Vanguard Medical Associates 1996 2012. Incident hyperthyroid hypothyroid cases were defined change in thyrotropin (TSH) normal (at baseline), low or high follow-up), respectively. In parallel analyses, hyper- matched euthyroid controls using incidence density sampling, ICM was ascertained claims data. Secondary analyses examined associations overt hypothyroidism (follow-up TSH≤0.1 mIU/L TSH>10 mIU/L, respectively). observed that [odds ratio, 1.61 (95% CI) 1.27-2.04], 1.62 1.08-2.43], ratio 2.01 1.25-3.23]. These thyroid functional disease an iodine-sufficient region.