Genesis of clone size heterogeneity in megakaryocytic and other hemopoietic colonies

摘要: Abstract Objective We previously showed that the distributions of numbers doublings (NbD) undergone by individual megakaryocyte progenitors before commitment to polyploidization are markedly skewed and can consistently be fitted straight lines when plotted on semilogarithmic coordinates. The slope such lines, which yields probability per doubling, is made less steep stimulators colony formation in mixed erythroid-megakaryocyte than pure colonies. Therefore, megakaryocytopoiesis provides a unique model for study clonal heterogeneity hemopoietic lineage, subject this review. Data Sources Articles relevant interpretation these data were selected from authors' public databases. Synthesis Exponential NbD first explained postulating following assembly thrombopoiesis-specific regulators, require only single random event arrest proliferation commit polyploidization. However, stochastic was refuted indicating intrinsic properties affect they achieve. suggest unequal repartition critical compounds (including receptors, signaling molecules, gene regulators) inherent stem cell-progenitor transition causes heritable progenitor responsiveness inducers. This would compatible with 1) evidence intraclonal synchronization other clones generated committed progenitors; 2) low relatively insensitive bipotent 3) thesis act part recruiting cells endowed lesser poly-ploidization inducers higher proliferative potential. Conclusion may major determinant exponential shape distributions.