The Transmission of AIDS: The Case of the Infected Cell

摘要: CURRENT approaches to preventing infection with the human immunodeficiency virus (HIV) have focused on retrovirus itself. However, biologic and epidemiologic studies of HIV acquired syndrome (AIDS) indicate that more emphasis should be placed virus-infected cell. Several groups researchers 1-10 demonstrated presence in many different hematopoietic cells, including T B lymphocytes macrophages, as See also p 3023. well cells (macrophages endothelial glial cells) brain. These infected can survive serve reservoirs (factories) for continual production spread. When found body fluids, they transfer other individuals. T-helper generally die after infection, 1-4 but some replicate high titer culture without undergoing cell death. 11 Thus, too could a source transmission. In from our laboratory,