Activation of the coagulation system in polycythemia vera
作者： A Carvalho , L Ellman
DOI: 10.1182/BLOOD.V47.4.669.BLOODJOURNAL474669
关键词: Factor XII 、 Antithrombin 、 Coagulation system 、 Gastroenterology 、 Medicine 、 Thrombosis 、 Fibrin 、 Coagulation 、 Prekallikrein 、 Immunology 、 Polycythemia vera 、 Internal medicine
摘要: Thrombosis is one of the major complications polycythemia vera. Seventeen patients with vera in good hematologic control were evaluated for abnormalities coagulation system. Activation intrinsic cascade was suggested by low levels factor XII, prekallikrein, and kallikrein inhibitors 12 17 patients. The group also demonstrated a significant increase soluble fibrin complexes using plasma gel filtration on 4% agarose. Fibrin degradation products normal antithrombin III slightly elevated. It appears that have chronic activation system, probably initiated XII. No correlation between degree thromboembolic evident this
ashpublications.org
bloodjournal.org参考文章(29)
L.R. Wasserman, H.S. Gilbert, COMPLICATIONS OF POLYCYTHEMIA VERA. Seminars Hematol., 3: 199-208(July 1966).. ,(1966)
F. Rodriguez-Erdmann, INTRAVASCULAR ACTIVATION OF THE CLOTTING SYSTEM WITH PHOSPHOLIPIDS. PRODUCTION OF THE GENERALIZED SHWARTZMAN REACTION WITH PLATELET FACTOR 3. Blood. ,vol. 26, pp. 541- 553 ,(1965) , 10.1016/S0006-4971(20)64435-4
Victor J. Marder, Myrtle O. Matchett, Sol Sherry, Detection of serum fibrinogen and fibrin degradation products The American Journal of Medicine. ,vol. 51, pp. 71- 82 ,(1971) , 10.1016/0002-9343(71)90325-1
Louis M. Aledort, John P. Hanson, Sam Berger, Louis R. Wasserman, Harriet S. Gilbert, Abnormalities of platelet function in patients with polycythemia vera. Cancer Research. ,vol. 33, pp. 2683- 2687 ,(1973)
L.O. Pilgeram, G. von dem Bussche, Thrombin mimetic effects of estrogen: II. Gel filtration and centrifugal evidence for estrogen induced polymerization of fibrinogen derivatives Thrombosis Research. ,vol. 6, pp. 19- 26 ,(1975) , 10.1016/0049-3848(75)90147-4
U. Abildgaard, Binding of Thrombin to Antithrombin III Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 24, pp. 23- 27 ,(1969) , 10.3109/00365516909080127
G. Mancini, A.O. Carbonara, J.F. Heremans, Immunochemical quantitation of antigens by single radial immunodiffusion Immunochemistry. ,vol. 2, pp. 235- 244 ,(1965) , 10.1016/0019-2791(65)90004-2
ROBERT W. COLMAN, The Kallikreinogen-Kallikrein Enzyme System of Human Plasma Annals of Internal Medicine. ,vol. 71, pp. 763- 773 ,(1969) , 10.7326/0003-4819-71-4-763
N. E. Stathakis, A. G. Papayannis, G. Arapakis, C. Gardikas, Haemostatic defects in polycythaemia vera. Annals of Hematology. ,vol. 29, pp. 77- 86 ,(1974) , 10.1007/BF01633831
M. K. Fagerhol, U. Abildgaard, Immunological studies on human antithrombin 3. Influence of age, sex and use of oral contraceptives on serum concentration. Scandinavian Journal of Haematology. ,vol. 7, pp. 10- 17 ,(2009) , 10.1111/J.1600-0609.1970.TB01862.X