Synthesis, Biodistribution, and Microsingle Photon Emission Computed Tomography (SPECT) Imaging Study of Technetium-99m Labeled PEGylated Dendrimer Poly(amidoamine) (PAMAM)-Folic Acid Conjugates

摘要: Three conjugates based on dendrimer PAMAM generation five were synthesized and radiolabeled successfully. To investigate their tumor targeting, the in vitro vivo stability, cell uptake, biodistribution, micro-SPECT imaging evaluated, respectively. The conjugate of (99m)Tc labeled PEGylated folic acid ((99m)Tc-G5-Ac-pegFA-DTPA) shows much higher uptake KB cancer cells accumulated more area than that other two conjugates. depends incubation time. results biodistribution agree with data obtained from imaging. These studies show PEGylation improves targeting. Folate-conjugated maybe developed to be potential radiopharmaceuticals targeted drug delivery systems.