Chloroquine resistant P. falciparum prevalence is low and unchanged between 1990 and 2005 in Guinea-Bissau: an effect of high chloroquine dosage?

作者: Johan Ursing , Berit Aydin Schmidt , Marianne Lebbad , Poul-Erik Kofoed , Fransisco Dias

DOI: 10.1016/J.MEEGID.2007.03.006

关键词: Chloroquine DoseChloroquine resistancePlasmodium falciparumGuinea bissauDrugBiologyChloroquinePharmacologyMalariaDrug resistance

摘要: Chloroquine resistant malaria was first reported in Guinea-Bissau 1990 but chloroquine remains the most commonly used antimalarial country. Since 1990, we have conducted nearly annual standardized WHO vitro micro-tests to assess resistance. We identified pfcrt 76T and other genetic polymorphisms samples from 1992, 1993, 1995, 2004 2005. also monitored drug prescriptions for febrile illnesses. The mean proportion of tests indicating resistance 33% (range 14-54%) with exception an outlying value year 2000. P. falciparum detected by testing did not increase over time. Pfcrt associated pfmdr1 86Y not. prevalence varied between 13% 38%. SNPs at positions 76, 271, 326 position 86 change significantly 1992 In a health centre median dose prescribed illnesses 1994 2003 63mg/kg. basis appears be same as countries. Despite that, has gradually increased 2005 Guinea-Bissau. is more than double normal Guinea Bissau. It previously been hypothesized that treatment high doses may effective. discuss possibility delayed spread result effective chloroquine.

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