Proteomic tissue profiling for the improvement of grading of noninvasive papillary urothelial neoplasia
作者： Rena F. Oezdemir , Nadine T. Gaisa , Katharina Lindemann-Docter , Sonja Gostek , Ralf Weiskirchen
DOI: 10.1016/J.CLINBIOCHEM.2011.09.013
关键词: Tumor marker 、 Histopathological grading 、 Nuclear medicine 、 Ionization time of flight 、 Chemistry 、 Mass spectrometry imaging 、 Pathology 、 Bladder cancer 、 MALDI imaging 、 Grading (education) 、 Reproducibility
摘要: Abstract Objectives In 2004, a novel grading system for papillary non-invasive bladder cancer was introduced; low grade (LG) and high (HG) in lieu of the former G1, G2, G3. This change allowed increased reproducibility as well diminished interobserver variability histopathological among individual pathologists. Matrix Assisted Laser Desorption/Ionization Time Flight Imaging Mass Spectrometry (MALDI TOF IMS) evaluated an automatic objective tool to assist urothelial neoplasms facilitate accuracy. Design methods To separate G1 (LG, n = 27) G3 (HG, n = 21) tumors MALDI IMS performed using appropriate algorithm. Thereafter, assignment G2 (n = 31) group completed. Results were separated with overall cross validation 97.18%. indicated true positive rate 78.3% LG 87.5% HG, respectively. Conclusions is powerful support ascertain pathological diagnosis/grading.
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