Serotonin inhibition of tumor necrosis factor-α synthesis by human monocytes
作者： Eduardo Arzt , Mónica Costas , S. Finkielman , Victor E. Nahmod
DOI: 10.1016/0024-3205(91)90612-F
关键词: Monocyte 、 Tumor necrosis factor alpha 、 Antagonist 、 Receptor 、 Internal medicine 、 Biology 、 Serotonin 、 Methysergide 、 Ketanserin 、 Endocrinology 、 Receptor antagonist 、 General Pharmacology, Toxicology and Pharmaceutics 、 General Biochemistry, Genetics and Molecular Biology 、 General Medicine
摘要: Serotonin inhibited in a concentration dependent way (10(-3) M to 10(-10) M) the LPS induced Tumor Necrosis Factor-alpha synthesis both, when added monocyte cultures from beginning and together with activating stimulus 8 hours before end of culture. The inhibitory effect was specifically blocked by 5-HT1 5-HT2 serotonin antagonist methysergide receptor ketanserin. This indicates that only family (5-HT2 or 5-HT1C) may be involved effect. seems play an important immunomodulatory role macrophage functions.
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sci-hub.se 参考文章(21)
O Bakke, A Waage, Glucocorticoids suppress the production of tumour necrosis factor by lipopolysaccharide-stimulated human monocytes. Immunology. ,vol. 63, pp. 299- 302 ,(1988)
C W Parker, M K Leung, E M Sternberg, H J Wedner, Effect of serotonin (5-HT) and other monoamines on murine macrophages: modulation of interferon-gamma induced phagocytosis. Journal of Immunology. ,vol. 138, pp. 4360- 4365 ,(1987)
Raymond A. Daynes, Gale A. Granger, Bryan T. Spofford, Cell-Mediated Immunity in Vitro: A Highly Sensitive Assay for Human Lymphotoxin Journal of Immunology. ,vol. 112, pp. 2111- 2116 ,(1974)
P W Askenase, R Meade, J C Ameisen, A new interpretation of the involvement of serotonin in delayed-type hypersensitivity. Serotonin-2 receptor antagonists inhibit contact sensitivity by an effect on T cells. Journal of Immunology. ,vol. 142, pp. 3171- 3179 ,(1989)
Anne W. Schmidt, Stephen J. Peroutka, 5-Hydroxytryptamine receptor "families". The FASEB Journal. ,vol. 3, pp. 2242- 2249 ,(1989) , 10.1096/FASEBJ.3.11.2673898
Eduardo S. Arzt, Silvia Fern�ndez-Castelo, Liliana M. E. Finocchiaro, Marcelo E. Criscuolo, Alberto D�az, Samuel Finkielman, V�ctor E. Nahmod, Immunomodulation by indoleamines: Serotonin and melatonin action on DNA and interferon-γ synthesis by human peripheral blood mononuclear cells Journal of Clinical Immunology. ,vol. 8, pp. 513- 520 ,(1988) , 10.1007/BF00916958
B Beutler, N Krochin, I. Milsark, C Luedke, A Cerami, Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance Science. ,vol. 232, pp. 977- 980 ,(1986) , 10.1126/SCIENCE.3754653
SILVIA FERNANDEZ-CASTELO, EDUARDO S. ARZT, ANALIA PESCE, MARCELO E. CRISCUOLO, ALBERTO DIAZ, SAMUEL FINKIELMAN, VICTOR E. NAHMOD, Angiotensin II regulates interferon-γ production Journal of interferon research. ,vol. 7, pp. 261- 268 ,(1987) , 10.1089/JIR.1987.7.261
Bruce Beutler, Anthony Cerami, Cachectin and tumour necrosis factor as two sides of the same biological coin Nature. ,vol. 320, pp. 584- 588 ,(1986) , 10.1038/320584A0
LILIANA M.E. FINOCCHIARO, EDUARDO S. ARZT, SILVIA FERNÁNDEZ-CASTELO, MARCELO CRISCUOLO, SAMUEL FINKIELMAN, VICTOR E. NAHMOD, Serotonin and Melatonin Synthesis in Peripheral Blood Mononuclear Cells: Stimulation by Interferon-7 as Part of an Immunomodulatory Pathway Journal of interferon research. ,vol. 8, pp. 705- 716 ,(1988) , 10.1089/JIR.1988.8.705