Can response to induction chemotherapy be a predictive marker for ultimate outcome in hypopharyngeal cancer

摘要: Objective Induction chemotherapy (ICT) may reduce rates of distant metastases and enhance organ preservation survival in patients with hypopharyngeal cancer. The authors compared data who underwent chemoradiotherapy or surgery after ICT investigated whether response to is a predictive marker for outcome Study design Historical cohort study. Setting Tertiary-care hospital. Subjects methods enrolled 97 (89 men, 8 women; mean age 61.2 years; range, 29-80 years) previously untreated cancer between January 1997 December 2006 at Asan Medical Center. Disease-free (DFS), overall (OS), laryngectomy-free (LFS) were analyzed. Results At follow-up 38.0 months, the 3-year DFS OS all 48.3% 49.2%, respectively. LFS rate nonsurgical therapy (n = 85) was 48.0%. Only associated (P .047), .003), .009) multivariate analysis. When surgical treatments ICT, they found that there no statistical difference terms partial (42.9% vs 50.5%, P .77) nonresponse groups (50.0% 0%, .43) 2 treatment types. Conclusion permits assessment tumor responsiveness alters subsequent accordingly. Response be useful prediction ultimate outcomes conservation