Induction chemotherapy with docetaxel and cisplatin followed by concomitant chemoradiotherapy in patients with inoperable non-nasopharyngeal carcinoma of the head and neck

摘要: Background: Induction chemotherapy (IC) followed by concomitant chemoradiotherapy (CCRT) has the potential of being an ideal multi-modality approach for improving prognosis patients with squamous cell carcinoma head and neck (SSCHN). Patients Methods: Thirty-four locally advanced SCCHN were treated 3 cycles IC, consisting docetaxel 75 mg/m 2 cisplatin every weeks, 3-4 weeks later definitive radiotherapy (70 Gy) weekly 40 . Results: After a median follow-up 27.7 months, 6-month progression-free survival (PFS), primary study end-point, was 84%. The PFS 16.4 months overall 24.4 months. majority completed IC mild to moderate toxicity. Anemia, nausea/vomiting mucositis prominent toxicities during CCRT. Retrospective analysis panel biomarkers suggested that excision repair cross-complementation group 1 (ERCC1) protein expression associated shorter PFS. Conclusion: CCRT, as administered in present study, is feasible well-tolerated therapeutic approach. However, its real impact on be demonstrated randomized comparing this treatment CCRT alone.