MMP9 but Not EGFR, MET, ERCC1, P16, and P-53 Is Associated with Response to Concomitant Radiotherapy, Cetuximab, and Weekly Cisplatin in Patients with Locally Advanced Head and Neck Cancer
作者： George Fountzilas , Anna Kalogera-Fountzila , Sophia Lambaki , Ralph M. Wirtz , Angelos Nikolaou
DOI: 10.1155/2009/305908
关键词: Head and neck cancer 、 Surgery 、 ERCC1 、 Cisplatin 、 Concomitant 、 Cetuximab 、 Internal medicine 、 Biomarker (medicine) 、 Radiation therapy 、 Medicine 、 Rash 、 Oncology
摘要: Concomitant administration of radiotherapy with cisplatin or cetuximab appear to be the treatment choice for patients locally advanced head and neck cancer. In present retrospective analysis, we investigated predictive role several biomarkers in an unselected cohort treated concomitant radiotherapy, weekly cisplatin, (CCRT). We identified 37 this approach, which 13 (35%) achieved a complete response 10 (27%) partial response. Severe side effects were mainly leucopenia, dysphagia, rash, anemia. Tumor EGFR, MET, ERCC1, p-53 protein and/or gene expression not associated contrast, high MMP9 mRNA was found significantly objective conclusion, CCRT is feasible active. only biomarker tested that appears value patients. However, hypothesis generating study results should viewed as definitive evidence until they are validated larger cohort.
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auth.gr参考文章(85)
Edwin Bölke*, Peter Arne Gerber*, Guido Lammering, Matthias Peiper, Anja Müller-Homey, Hildegard Pape, Christian Giro, Christiane Matuschek, Daniela Bruch-Gerharz, Thomas K. Hoffmann, Stephan Gripp, Bernhard Homey*, Wilfried Budach*, Development and management of severe cutaneous side effects in head-and-neck cancer patients during concurrent radiotherapy and cetuximab. Strahlentherapie Und Onkologie. ,vol. 184, pp. 105- 110 ,(2008) , 10.1007/S00066-008-1829-Z
Barbara Dietl, Jörg Marienhagen, Christof Schaefer, Fabian Pohl, Oliver Kölbl, Häufigkeit und Topographie von Fernmetastasen bei Patienten mit HNO-Tumoren und ihre onsequenzen für das prätherapeutische Staging Strahlentherapie Und Onkologie. ,vol. 183, pp. 138- 143 ,(2007) , 10.1007/S00066-007-1611-7
Jonathan M. Bock, Shyh-Min Huang, Paul M. Harari, Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Research. ,vol. 59, pp. 1935- 1940 ,(1999)
Christina Schütze, Annegret Dörfler, Wolfgang Eicheler, Daniel Zips, Sandra Hering, Flavio Solca, Michael Baumann, Mechthild Krause, Combination of EGFR/HER2 tyrosine kinase inhibition by BIBW 2992 and BIBW 2669 with irradiation in FaDu human squamous cell carcinoma. Strahlentherapie Und Onkologie. ,vol. 183, pp. 256- 264 ,(2007) , 10.1007/S00066-007-1696-Z
Gabriela Studer, Urs M. Luetolf, Christoph Glanzmann, Locoregional Failure Analysis in Head-and-Neck Cancer Patients Treated with IMRT Strahlentherapie Und Onkologie. ,vol. 183, pp. 417- 423 ,(2007) , 10.1007/S00066-007-1663-8
Nikolaos Zamboglou, George Fountzilas, Thomas Zaramboukas, Anna Kalogera-Fountzila, Konstantine T Kalogeras, Paris Kosmidis, Georgia Karayannopoulou, Mattheos Bobos, Eleni Athanassiou, Despina Misailidou, Aristotelis Bamias, Pavlos Papakostas, Christos Tolis, Periklis Tsekeris, Chrysanthi Vamvouka, Induction chemotherapy with docetaxel and cisplatin followed by concomitant chemoradiotherapy in patients with inoperable non-nasopharyngeal carcinoma of the head and neck Anticancer Research. ,vol. 29, pp. 529- 538 ,(2009)
Axel Walch, Karin Bink, Peter Hutzler, Katharina Böwering, Ioanna Letsiou, Horst Zitzelsberger, Herbert Braselmann, Hubert Stein, Heinz Höfler, Martin Werner, None, Sequential Multilocus Fluorescence In Situ Hybridization Can Detect Complex Patterns of Increased Gene Dosage at the Single Cell Level in Tissue Sections Laboratory Investigation. ,vol. 81, pp. 1457- 1459 ,(2001) , 10.1038/LABINVEST.3780359
George Fountzilas, Mattheos Bobos, Anna Kalogera-Fountzila, Nikolaos Xiros, Samuel Murray, Helena Linardou, Georgia Karayannopoulou, Angelos K. Koutras, Dimitrios Bafaloukos, Epaminondas Samantas, Christos Christodoulou, Theofanis Economopoulos, Konstantine T. Kalogeras, Paris Kosmidis, Gemcitabine combined with gefitinib in patients with inoperable or metastatic pancreatic cancer: a phase II Study of the Hellenic Cooperative Oncology Group with biomarker evaluation. Cancer Investigation. ,vol. 26, pp. 784- 793 ,(2008) , 10.1080/07357900801918611
Masakazu Nakajima, Hidetomo Sawada, Yukishige Yamada, Akihiko Watanabe, Mitsutoshi Tatsumi, Jun Yamashita, Masahiko Matsuda, Teruyuki Sakaguchi, Tomoko Hirao, Hiroshige Nakano, The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas. Cancer. ,vol. 85, pp. 1894- 1902 ,(1999) , 10.1002/(SICI)1097-0142(19990501)85:9<1894::AID-CNCR3>3.0.CO;2-J
Min Yao, Michael M. Graham, Russell B. Smith, Kenneth J. Dornfeld, Mark Skwarchuk, Henry T. Hoffman, Gerry F. Funk, Scott M. Graham, Yusuf Menda, John M. Buatti, Value of FDG PET in assessment of treatment response and surveillance in head-and-neck cancer patients after intensity modulated radiation treatment: A preliminary report International Journal of Radiation Oncology Biology Physics. ,vol. 60, pp. 1410- 1418 ,(2004) , 10.1016/J.IJROBP.2004.05.058