Hidradenitis suppurativa: A practical review of possible medical treatments based on over 350 hidradenitis patients

摘要: Hidradenitis suppurativa (HS), a pathological follicular disease, impacts patients' lives profoundly. HS most commonly involves cutaneous intertriginous areas, such as the axilla, inner thighs, groin and buttocks, pendulous breasts, but can appear on any skin. Protean, manifests with variations of abscesses, folliculitis, pyogenic granulomas, scars (oval honeycombed), comedones, tracts, fistulas, keloids. The pathophysiology might involve both defects innate immunity overreaction to coagulase negative Staphylococcus. Treatment depends morphology, extent, severity, duration. Topical clindamycin dapsone are often adequate for treating mild HS. For Stage 1 2 HS, first line treatment combines rifampin either oral or minocycline. Other treatments include: fluoroquinolones metronidazole rifampin, dapsone, zinc, acitretin, hormone blockers (oral contraceptive pills, spironolactone, finasteride, dutasteride), prednisone. severe cyclosporine, adalimumab, infliximab (used at double psoriatic doses) intravenous carbapenems cephalosporins required. Isotretinoin, etanercept, isoniazid, lymecycline, sulfasalazine, methotrexate, metformin, colchicine, clarithromycin, IVIG, thalidomide less favored treatments. role botulinum toxin is uncertain. important life style modification weight loss. De-roofing fluctuant nodules injection intralesional corticosteroids ameliorates disease perhaps, if done regular intervals, improves more permanently. Surgical excision CO2 laser ablation definitive 1064 nm hair removal aids in This article centers medical therapies will only passingly mention surgical summarizes my experience over 350 patients.