Dehydroevodiamine·HCl Improves Stress-Induced Memory Impairments and Depression Like Behavior in Rats.
作者： Hee Jin Kim , Ki Young Shin , Keun-A Chang , Sangzin Ahn , Hee Soon Choi
DOI: 10.4196/KJPP.2014.18.1.55
关键词: Cognitive disturbance 、 Behavioural despair test 、 Fluoxetine 、 Depression (differential diagnoses) 、 Neural cell adhesion molecule 、 Stress induced 、 Memory impairment 、 Neuroscience 、 Dehydroevodiamine 、 Medicine 、 Psychiatry
摘要: Dehydroevodiamine·HCl (DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on behavioral abnormality caused by stress. demonstrated that can improve stress-induced impairments depression-like behaviors using open-field test, Y-maze test forced swimming test. treatment significantly recovered decreases levels neural adhesion molecule (NCAM) proteins stress viability. Our results suggested is potential drug candidate for death, depression induced
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