Effects of naloxone on membrane potential of identified neurons of Helix aspersa.
作者： Rafael Gutiérrez
DOI: 10.1016/0742-8413(92)90298-L
关键词: Electrophysiology 、 Nervous system 、 Internal medicine 、 Membrane potential 、 Neuron 、 Opioid peptide 、 (+)-Naloxone 、 Opioid 、 Biology 、 Endocrinology 、 Inhibitory postsynaptic potential
摘要: Abstract 1. The action of naloxone, at doses that antagonize the inhibitory actions opioid agonists in mammals, was tested identified cells Helix aspersa . 2. Naloxone able to modify membrane potential some without prior exposure opiate agonists. Some were depolarized and others hyperpolarized. 3. Met-enkephalin also effective eliciting changes cells, failed others, which responded partially effect naloxone. 4. electrophysiological responsiveness this preparation antagonists makes mollusc a suitable model for study dependence naloxone pharmacology.
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