Effects of human placenta-derived mesenchymal stem cells with NK4 gene expression on glioblastoma multiforme cell lines.
作者： Zahra Jabbarpour , Jafar Kiani , Somayeh Keshtkar , Massoud Saidijam , Mohammad H. Ghahremani
DOI: 10.1002/JCB.29371
关键词: Glioblastoma 、 Apoptosis 、 Biology 、 Drug delivery 、 Cancer research 、 Mesenchymal stem cell 、 Hepatocyte growth factor 、 Gene expression 、 Cell culture 、 Human placenta
摘要: Poor prognosis and low survival are commonly seen in patients with glioblastoma multiforme (GBM). Due to the specific nature of solid tumors such as GBM, delivery therapeutic agents tumor sites is difficult. So, one major challenges treatment these a selection appropriate method for drug delivery. Mesenchymal stem cells (MSCs) have unique characteristic migration toward tissue. In this regard, present study examined antitumor effects manipulating human placenta-derived mesenchymal (PDMSCs) NK4 expression (PDMSC-NK4) on GBM cells. After separation characterization PDMSCs, were transduced which was known antagonist hepatocyte growth factor (HGF). The results indicated that engineered PDMSCs preferably migrate into by transwell coculture system. addition, proliferation significantly reduced after fact, manipulated inhibited induction apoptosis. Our findings suggested besides having effects, can also be applied an ideal cellular vehicle target multiforme.
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