The response of NG2-expressing oligodendrocyte progenitors to demyelination in MOG-EAE and MS

摘要: Remyelination of primary demyelinated lesions is a common feature experimental models multiple sclerosis (MS) and also suggested to be the normal response demyelination during early stages MS itself. Many lines evidence have shown that remyelination preceded by division endogenous oligodendrocyte precursor cells (OPCs) in lesion its borders. It this rapid OPCs repopulate site their subsequent differentiation into new oligodendrocytes key remyelination. Antibodies NG2 chondroitin sulphate proteoglycan proved exceedingly useful following quantitating demyelination. Here we review literature on NG2-expressing provide some chronic inflammatory demyelinating environment seen recombinant myelin glycoprotein (MOG) induced allergic encephalomyelitis (EAE) DA rat. responded model becoming reactive increasing number very focal manner. Evidence NG2+OPCs lesioned areas beginning express marker CNP was seen. The appeared occur successive relapses but did not always lead remyelination, with observed spinal cord. presence adult human CNS clearly vital importance for repair (MS). As rat tissue, antibody labels an evenly distributed cell population present both white grey matter, distinct from HLA-DR+microglia. NG2+cells are sparsely centre lesions. These apparently survive exhibit multi-processed or bipolar morphology hypocellular lesion.