Metabolites of Trichoderma species isolated from damp building materials.

摘要: Buildings that have been flooded often high concentrations of Trichoderma spores in the air while drying. Inhaled and spore mycelial fragments contain large amounts fungal glucan natural products contribute to symptoms associated with indoor mould exposures. In this study, we considered both small molecules peptaibol profiles T. atroviride, koningiopsis, citrinoviride, harzianum strains obtained from damp buildings eastern Canada. Twenty-residue peptaibols sorbicillin-derived metabolites (1-6) including a new structure, (R)-vertinolide (1), were characterized citrinoviride. koningiopsis produced several koninginins (7-10), trikoningin KA V, 11-residue lipopeptaibols KB I II. atroviride biosynthesized mixture 19-residue trichorzianine-like peptaibols, whereas 18-residue trichokindin-like harzianin HB was subsequently identified studied citrinoviride strain. Two α-pyrones, 6-pentyl-pyran-2-one (11) an oxidized analog (12), by harzianum. Aside exposure low molecular weight products, inhalation may result membrane-disrupting peptaibols. This investigation contributes more comprehensive understanding biologically active fungi commonly found buildings.