Beta blockade with pindolol: Differential cardiac and renal effects despite similar plasma kinetics in normal and uremic man
作者： Renato L. Galeazzi , Matthias Gugger , Peter Weidmann
DOI: 10.1038/KI.1979.86
关键词: Heart rate 、 Internal medicine 、 Blockade 、 Plasma kinetics 、 Endocrinology 、 Medicine 、 Aldosterone 、 Beta (finance) 、 Pindolol 、 Nephrology
摘要: Beta blockade with pindolol: Differential cardiac and renal effects despite similar plasma kinetics in normal uremic man. Cardiac (measured as the reduction exercise-induced tachycardia PRA, respectively) circulating drug concentrations after acute beta intravenous pindolol were compared between seven volunteers six patients terminal failure. Kinetic parameters both groups (total body clearance, 450 ml/min), indicating enhanced extrarenal elimination patients. For any given concentration, however, responded to a greater decrease pulse rate than did (P Blocage par le Effets cardiaque et differents malgre une cinetique plasmatique semblable, chez l'homme uremique. Les effets (mesures respectivement la de tachycardie d'effort PRA) les circulantes drogue apres bloc aigu intraveineux ont ete compares entre sept volontaires normaux malades atteints d'insuffisance renale terminale. parametres cinetiques sont semblables dans deux groupes (clearance totale, ce qui indique extra-renale augmentee uremiques. Cependant, pour concentration donnee drogue, repondent diminution plus grande frequence que
core.ac.uk
kidney-international.org
elsevier.com
nature.com
sci-hub.se 参考文章(30)
John G. Wagner, Fundamentals of Clinical Pharmacokinetics ,(1975)
Alvin L. Sellers, Shaul G. Massry, Clinical aspects of uremia and dialysis Thomas. ,(1976)
D. LAVENE, Y. A. WEISS, M. E. SAFAR, Y. LORIA, N. AGORUS, D. GEORGES, P. L. MILLIEZ, Pharmacokinetics and Hepatic Extraction Ratio of Pindolol in Hypertensive Patients with Normal and Impaired Renal Function The Journal of Clinical Pharmacology. ,vol. 17, pp. 501- 508 ,(1977) , 10.1002/J.1552-4604.1977.TB05643.X
Wilhelm Vetter, Hans Vetter, Walter Siegenthaler, Radioimmunoassay for aldosterone without chromatography. European Journal of Endocrinology. ,vol. 74, pp. 548- 557 ,(1973) , 10.1530/ACTA.0.0740548
E L Bravo, R C Tarazi, H P Dustan, J W Lewis, Dissociation between renin and arterial pressure responses to beta-adrenergic blockade in human essential hypertension. Circulation Research. ,vol. 36, pp. 241- 247 ,(1975) , 10.1161/01.RES.36.6.241
David Hirsch, Morton H. Maxwell, Ronald Okun, Phillip Schroth, Peter Weidmann, Plasma renin and blood pressure during treatment with methyldopa. American Journal of Cardiology. ,vol. 34, pp. 671- 676 ,(1974) , 10.1016/0002-9149(74)90156-8
G. Bianchetti, G. Graziani, D. Brancaccio, A. Morganti, G. Leonetti, M. Manfrin, R. Sega, R. Gomeni, C. Ponticelli, P. L. Morselli, Pharmacokinetics and Effects of Propranolol in Terminal Uraemic Patients and in Patients Undergoing Regular Dialysis Treatment Clinical Pharmacokinectics. ,vol. 1, pp. 373- 384 ,(1976) , 10.2165/00003088-197601050-00004
F Skrabal, W Czaykowska, P Dittrich, H Braunsteiner, Immediate plasma renin response to propranolol: differentiation between essential and renal hypertension. BMJ. ,vol. 2, pp. 144- 147 ,(1976) , 10.1136/BMJ.2.6028.144
A. LINDNER, Propranolol Effects in Long-Term Hemodialysis Patients with Renin-Dependent Hypertension Annals of Internal Medicine. ,vol. 88, pp. 457- 462 ,(1978) , 10.7326/0003-4819-88-4-457
Josef Flammer, Peter Weidmann, Zeev Glück, Walter H. Ziegler, Francois C. Reubi, Cardiovascular and endocrine profile of adrenergic neurone blockade in normal and hypertensive man The American Journal of Medicine. ,vol. 66, pp. 34- 42 ,(1979) , 10.1016/0002-9343(79)90479-0