Patient perception of medication benefit and early treatment discontinuation in a 1-year study of patients with schizophrenia.

摘要: OBJECTIVE The objective of this study was to examine the relationship between patient beliefs about medication use and their likelihood discontinuing treatment prematurely. Associations with clinical psychopathology life satisfaction were also assessed. METHODS This post-hoc analysis used data from a randomized, open label, 1-year trial antipsychotics in patients schizophrenia or schizoaffective disorders (N = 664). Medication management including dosage adjustment switching at doctors' discretion, reflecting naturalistic usual care settings. Early discontinuation defined as all-cause drop out. Patient-reported assessed by Rating Influences (ROMI), degree measured Positive Negative Syndrome Scale (PANSS), quality Lehman Quality Life Interview (LQLI). RESULTS Patient perception benefit only strong predictor duration among 5 underlying dimensions influence. Higher level perceived beneficial effect associated reduced risk early (Hazard ratio 0.56, 95% Confidence Interval [0.40, 0.79], p 0.001). Patients greater had better outcome more satisfied well-being. CONCLUSION Understanding predictors is important for development interventions improve outcome. Current findings suggest that may be critical factor achieving persistence satisfactory