Total Synthesis of (−)-Colchicine by an Oxyallyl [4+3] Cycloaddition
作者： Jae Chol Lee , Jin Kun Cha
DOI: 10.1016/S0040-4020(00)00862-0
关键词: Chemistry 、 Cycloaddition 、 Intramolecular force 、 Total synthesis 、 Organic chemistry 、 Enantioselective synthesis 、 Tandem 、 Isocolchicine 、 Biochemistry 、 Drug discovery
摘要: … The desired cycloadduct 7 (R 1 =O-t-Bu) was indeed obtained as a single diastereomer in 45% yield (based on 50% conversion of the starting material). Regiochemistry was firmly …
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